Study Comparing Mocertatug Rezetecan with Chemotherapy for Endometrial Cancer After Previous Treatments

Inclusion Criteria

• Must be at least 18 years old and legally able to consent to participate.
• Must have a confirmed diagnosis of endometrial cancer, including specific types like endometrioid, serous, clear cell, or carcinosarcoma.
• Must have had 1 to 2 previous treatments for endometrial cancer, or up to 3 if one was given before or after surgery.
• Must have cancer that has worsened after platinum-based chemotherapy and have received PD-1/PD-L1 therapy, unless unsuitable for such treatment.
• Must have a platinum-free interval of less than 12 months if only treated with platinum-based therapy after surgery.
• Must provide a tumor sample for testing a specific protein (B7-H4) before starting the study.
• Must have at least one measurable tumor.
• Must agree to use effective birth control during the study and for 8 months after the last dose if of childbearing potential.
• Must not be pregnant or breastfeeding and must have a negative pregnancy test before starting the study.
• Must be able to give informed consent and follow study requirements.
• Must have a performance status indicating good overall health (ECOG 0 or 1).
• Must have adequate organ function.

Exclusion Criteria

• Cannot have certain types of uterine cancer like uterine sarcomas or neuroendocrine cancer.
• Cannot have another cancer that has needed treatment in the last 3 years, except for certain skin cancers or in-situ cancers that have been treated.
• Cannot have had a bone marrow or organ transplant.
• Cannot have allergies to the study drugs or their components.
• Cannot have untreated or worsening brain or CNS metastases.
• Cannot have a history of lung disease or pneumonitis.
• Cannot have unresolved side effects from previous treatments, except for certain conditions like hair loss or stable conditions.
• Cannot have serious medical or psychiatric conditions that could interfere with the study.
• Cannot have had major surgery or certain treatments recently.
• Cannot have received certain investigational or anti-cancer drugs recently.
• Cannot have received a live vaccine recently.
• Cannot have certain infections like HIV with specific criteria, or active hepatitis B or C.
• Cannot have significant heart or kidney conditions.