Study Comparing ABBV-1480 with Chemotherapy to Pembrolizumab with Chemotherapy for First-Line Treatment of Advanced Non-Small Cell Lung Cancer

Sponsor: AbbVie

Sponsor score: 60

ClinicalTrials ID:NCT07756645

Provider View

This clinical trial is testing whether a new drug, ABBV-1480, combined with chemotherapy, is more effective than the standard treatment of pembrolizumab with chemotherapy for adults with advanced non-small cell lung cancer (NSCLC).

Patient Parameters

Program Overview

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. This study aims to find out if a new drug, ABBV-1480, combined with chemotherapy, works better than the current standard treatment, pembrolizumab with chemotherapy, for adults with advanced NSCLC. Participants will be randomly assigned to receive either ABBV-1480 with chemotherapy or pembrolizumab with chemotherapy. The study will involve about 940 adults with advanced or metastatic NSCLC at around 250 locations worldwide. Participants will have regular check-ups, including medical assessments, blood tests, and questionnaires, to monitor the treatment's effects and any side effects.

Eligibility Criteria

Inclusion Criteria

  • Adults diagnosed with advanced or metastatic squamous non-small cell lung cancer (sqNSCLC) that cannot be cured with surgery.
  • Have at least one tumor that can be measured by scans.
  • Tumors in areas previously treated with radiation can be included if they have grown since treatment.
  • Be in good overall health, with a performance status score of 0 or 1, meaning fully active or restricted in physically strenuous activity but ambulatory.
  • Have adequate blood, kidney, liver, and clotting function.
  • Women who can become pregnant must have a negative pregnancy test.

Exclusion Criteria

  • Have received previous treatment for advanced or metastatic NSCLC.
  • Have a type of lung cancer other than squamous NSCLC.
  • Have specific genetic changes in the cancer for which there are approved treatments.
  • Have active cancer that has spread to the brain or spinal cord.

Locations

FACILITYZIPCITYSTATE
Fort Wayne Medical Oncology And Hematology /ID# 28650146804Fort WayneIndiana

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